Indications Listed in Dosage.
Dosage Adult: PO Osteolytic bone metastases 1.6 g/day. Max: 3.2 g/day. IV Hypercalcaemia of malignancy 300 mg/day until normocalcaemia. Treatment duration should not exceed 10 days.
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Administration Should be taken on an empty stomach. (Take on an empty stomach w/ a glass of plain water at least 1 hr before or after food. Remain in an upright position for at least ½ hr . Do not take w/ milk, food or products containing Ca or other polyvalent cations. Tab may be divided only along the score-line. Swallow cap/tab whole or divided halves of tab, do not chew/crush.)
Overdosage For action to be taken in the event of accidental overdose ... click to view clodronic acid
Contraindications Moderate to severe renal insufficiency; acute upper GI inflammation; hypersensitivity to bisphosphonates; pregnancy and lactation.
Special Precautions Monitor white cell count, serum Ca and phosphate levels, hepatic and renal functions.
Adverse Drug Reactions GI disturbances; musculoskeletal pain; headache; moderate leucopenia; transient proteinuria after IV infusion; electrolyte disturbances; hypersensitivity reactions; local reactions (parenteral); renal impairment (parenteral), bronchospasm.
Drug Interactions Aluminum, calcium, iron, Mg compounds; NSAIDs; increased risk of nephrotoxicity with aminoglycosides.
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Food Interaction For caution against potential drug-food interactions ... click to view clodronic acid
Mechanism of Action For details of the mechanism of action, pharmacology and pharmacokinetics and toxicology ... click to view clodronic acid
MIMS Class Agents Affecting Bone Metabolism
ATC Classification M05BA02 - clodronic acid ; Belongs to the class of bisphosphonates. Used in the treatment of bone diseases.